Astrocytes, through their close associations with synapses, can monitor and alter synaptic
function, thus actively controlling synaptic transmission in the adult brain. Besides their …

Stroke remains a leading cause of death and disability in the world. Over the past few
decades our understanding of the pathophysiology of stroke has increased, but greater …

One of the landmark events of the past 25 years in neuroscience research was the
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …

Dysregulated neurodevelopment with altered structural and functional connectivity is
believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Forty years since the initial discovery of neurogenesis in the postnatal rat hippocampus,
investigators have now firmly established that active neurogenesis from neural progenitors …

Accumulating evidence from animal and human research indicate that adult hippocampal
neurogenesis plays a key role in cognition. Meanwhile, cognitive decline is well known to …

Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate
neurons following forced expression of neurogenic transcription factors, thus opening new …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …