Severe acute brain injury (SABI) accounts for up to 25% of individuals receiving mechanical
ventilation (MV). 1, 2 Yet, there are insufficient data to inform ventilatory targets in this …

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Rationale: Whether extubation immediately after a successful spontaneous breathing trial is
associated with clinical benefits in adult patients with acute brain injury is unknown …

OBJECTIVES: To evaluate the association between the pre-extubation sum of eye and
motor components of the Glasgow Coma Score (GCS-EM) and odds of extubation failure in …

Background/Objectives: Non-invasive respiratory support and invasive mechanical
ventilation are critical interventions that can induce significant changes not only in the lungs …

Background: Acute respiratory distress syndrome (ARDS) is an important pulmonary
complication in brain-injured patients receiving invasive mechanical ventilation (IMV). We …

Extubation is a crucial step in the weaning process of critically ill mechanically ventilated
patients. Some patients may develop postextubation respiratory failure that may lead to the …

Prophylactic respiratory support for patients after extubation is effective in improving their
outcomes and prognosis. However, the optimal post-extubation respiratory support for …

Current international guidelines for management of septic shock suggest the usage of
corticosteroids for adults with an ongoing requirement for vasopressor therapy, based on …

We would like to thank Li et al. for their thoughtful comments on our study 1. We agree with
their primary message that high flow nasal cannula (HFNC) or non-invasive positive …