Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition
characterised by impulsivity, inattention and hyperactivity. Aside from these core …

Acute sleep deprivation is a common condition in modern life and increases anxiety
symptoms in healthy individuals. The neuroinflammatory response induced by microglial …

The mammalian circadian and sleep-wake systems are closely aligned through their
coordinated regulation of daily activity patterns. Although they differ in their anatomical …

Background Soluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain
one to two decades before a clinical diagnosis of Alzheimer's disease (AD). The literature …

Abstract Study Objectives Aggregates of hyperphosphorylated tau protein are a hallmark of
Alzheimer's disease (AD) and other tauopathies. Sleep disturbances are common in AD …

The Eph receptor, a prototypically large receptor protein tyrosine kinase, interacts with
ephrin ligands, forming a bidirectional signaling system that impacts diverse brain functions …

The fragile X autosomal homolog 1 (Fxr1) is regulated by lithium and has been GWAS‐
associated with schizophrenia and insomnia. Homeostatic regulation of synaptic strength is …

Highlights•Acute sleep loss modifies synaptic structure in a region-dependent
manner.•Sleep loss mostly reduces dendritic spine number in the mammalian …

The suprachiasmatic nucleus (SCN) is the central circadian clock in mammals. It is entrained
by light but resistant to temperature shifts that entrain peripheral clocks [1–5]. The SCN …

Background Sleep disturbances are a common comorbidity to most neurodevelopmental
disorders and tend to worsen disease symptomatology. It is thus crucial to understand …