Dental enamel formation and implications for oral health and disease

RS Lacruz, S Habelitz, JT Wright… - Physiological …, 2017‏ - journals.physiology.org
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …

Molecular and cellular mechanisms of tooth development, homeostasis and repair

T Yu, OD Klein - Development, 2020‏ - journals.biologists.com
The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

J Krivanek, RA Soldatov, ME Kastriti… - Nature …, 2020‏ - nature.com
Understanding cell types and mechanisms of dental growth is essential for reconstruction
and engineering of teeth. Therefore, we investigated cellular composition of growing and …

Cellular and molecular mechanisms of tooth root development

J Li, C Parada, Y Chai - Development, 2017‏ - journals.biologists.com
The tooth root is an integral, functionally important part of our dentition. The formation of a
functional root depends on epithelial-mesenchymal interactions and integration of the root …

An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice

JKH Hu, W Du, SJ Shelton, MC Oldham, CM DiPersio… - Cell stem cell, 2017‏ - cell.com
Tissue homeostasis requires the production of newly differentiated cells from resident adult
stem cells. Central to this process is the expansion of undifferentiated intermediates known …

Tissue interactions regulating tooth development and renewal

A Balic, I Thesleff - Current topics in developmental biology, 2015‏ - Elsevier
Reciprocal interactions between epithelial and mesenchymal tissues play a fundamental
role in the morphogenesis of teeth and regulate all aspects of tooth development. Extensive …

Joint development involves a continuous influx of Gdf5-positive cells

Y Shwartz, S Viukov, S Krief, E Zelzer - Cell reports, 2016‏ - cell.com
Synovial joints comprise several tissue types, including articular cartilage, the capsule, and
ligaments. All of these compartments are commonly assumed to originate from an early set …

Intertwined signaling pathways governing tooth development: a give-and-take between canonical Wnt and Shh

F Hermans, L Hemeryck, I Lambrichts… - Frontiers in cell and …, 2021‏ - frontiersin.org
Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …

Tissue engineering approaches for enamel, dentin, and pulp regeneration: an update

GM Ahmed, EA Abouauf, N AbuBakr… - Stem Cells …, 2020‏ - Wiley Online Library
Stem/progenitor cells are undifferentiated cells characterized by their exclusive ability for self‐
renewal and multilineage differentiation potential. In recent years, researchers and …

Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma

G **ong, N **e, M Nie, R Ling, B Yun, J **e… - International Journal of …, 2024‏ - nature.com
Ameloblastoma is a benign tumor characterized by locally invasive phenotypes, leading to
facial bone destruction and a high recurrence rate. However, the mechanisms governing …