Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER
stress, eukaryotic cells commonly provoke a protective gene expression program called the …

Hac1p is a key transcription factor regulating the unfolded protein response (UPR) induced
by abnormal accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) …

Dermatomycosis is an infection with global impacts caused especially by dermatophytes
and Candida species. Current antifungal therapies involve drugs that face fungal resistance …

The emergence of azole resistance and tolerance in pathogenic fungi has emerged as a
significant public health concern, emphasizing the urgency for innovative strategies to …

Translation of HAC1 mRNA in the budding yeast Saccharomyces cerevisiae is derepressed
when RNase Ire1 removes its intron via nonconventional cytosolic splicing in response to …

Fungal HacA/Hac1 transcription factors play a crucial role in regulating the unfolded protein
response (UPR). The UPR helps cells to maintain endoplasmic reticulum (ER) protein …

Candida parapsilosis is a major fungal pathogen that leads to sepsis. New and more
effective antifungal agents are required due to the emergence of resistant fungal strains …

Candida parapsilosis has emerged as a frequent cause of invasive candidiasis with
increasing evidence of unique biological features relative to C. albicans. As it adapts to …

The basic leucine zipper (bZIP) transcription factor (TF) family, one of the largest and the
most diverse TF families, is widely distributed across the eukaryotes. It has been described …

Fungi rely on the unfolded protein response (UPR) to rapidly adapt the secretory pathway for
efficient nutrient mobilization and communication with and alteration of the abiotic and biotic …