Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Cryo-EM in drug discovery: achievements, limitations and prospects
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …
technique that can be used to determine the structure of biological macromolecules and …
Organic carbamates in drug design and medicinal chemistry
The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are …
is an increasing use of carbamates in medicinal chemistry and many derivatives are …
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …
transforming this deadly ailment into a more manageable chronic infection. Over the years …
The structural biology of HIV-1: mechanistic and therapeutic insights
Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …
mechanisms and, for cases in which the molecular function affects human health, can …
Boron containing compounds as protease inhibitors
Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …
Structure-based strategies for drug design and discovery
ID Kuntz - Science, 1992 - science.org
Most drugs have been discovered in random screens or by exploiting information about
macromolecular receptors. One source of this information is in the structures of critical …
macromolecular receptors. One source of this information is in the structures of critical …
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design
▪ Abstract Retroviral protease (PR) from the human immunodeficiency virus type 1 (HIV-1)
was identified over a decade ago as a potential target for structure-based drug design. This …
was identified over a decade ago as a potential target for structure-based drug design. This …
HIV-1 protease: mechanism and drug discovery
It has now been two decades since acquired immunodeficiency syndrome (AIDS) was first
reported by the US Center for Diseases Control (CDC). A few years later, it was found that a …
reported by the US Center for Diseases Control (CDC). A few years later, it was found that a …
[HTML][HTML] HIV protease: Historical perspective and current research
The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for
antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to …
antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to …
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
Mechanistic information and structure-based design methods have been used to design a
series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus …
series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus …