The state of technological advancement to address challenges in the manufacture of rAAV gene therapies
Current processes for the production of recombinant adeno-associated virus (rAAV) are
inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews …
inadequate to meet the surging demand for rAAV-based gene therapies. This article reviews …
Peptide ligands for the universal purification of exosomes by affinity chromatography
RE Kilgore, BD Moore, SA Sripada… - Biotechnology and …, 2024 - Wiley Online Library
Exosomes are gaining prominence as vectors for drug delivery, vaccination, and
regenerative medicine. Owing to their surface biochemistry, which reflects the parent cell …
regenerative medicine. Owing to their surface biochemistry, which reflects the parent cell …
The downstream bioprocess toolbox for therapeutic viral vectors
Viral vectors are poised to acquire a prominent position in modern medicine and
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
biotechnology owing to their role as delivery agents for gene therapies, oncolytic agents …
Peptide ligands targeting the vesicular stomatitis virus G (VSV‐G) protein for the affinity purification of lentivirus particles
E Barbieri, GN Mollica, BD Moore… - Biotechnology and …, 2024 - Wiley Online Library
The recent uptick in the approval of ex vivo cell therapies highlights the relevance of
lentivirus (LV) as an enabling viral vector of modern medicine. As labile biologics, however …
lentivirus (LV) as an enabling viral vector of modern medicine. As labile biologics, however …
Affinity chromatography for virus-like particle manufacturing: challenges, solutions, and perspectives
J Ma, Z Tian, Q Shi, X Dong, Y Sun - Journal of Chromatography A, 2024 - Elsevier
The increasing medical application of virus-like particles (VLPs), notably vaccines and viral
vectors, has increased the demand for commercial VLP production. However, VLP …
vectors, has increased the demand for commercial VLP production. However, VLP …
Rational design and experimental evaluation of peptide ligands for the purification of adeno‐associated viruses via affinity chromatography
Adeno‐associated viruses (AAVs) have acquired a central role in modern medicine as
delivery agents for gene therapies targeting rare diseases. While new AAVs with improved …
delivery agents for gene therapies targeting rare diseases. While new AAVs with improved …
Peptide ligands for the affinity purification of adenovirus from HEK293 and vero cell lysates
Adenovirus (AdVs) is the viral vector of choice in vaccines and oncolytic applications owing
to its high transduction activity and inherent immunogenicity. For decades, AdV isolation has …
to its high transduction activity and inherent immunogenicity. For decades, AdV isolation has …
Enhancing the performance limits of hydrophobic charge-induction chromatography with the introduction of a second ligand
W Shi, SQ Zhang, KB Li, XB Zhang, CY Fang… - Biochemical …, 2024 - Elsevier
Traditional chromatography often faces issues such as high cost and insufficient selectivity,
driving a continuous demand for improved technologies. Current chromatography primarily …
driving a continuous demand for improved technologies. Current chromatography primarily …
[HTML][HTML] Efficient AAV9 Purification Using a Single-Step AAV9 Magnetic Affinity Beads Isolation
KC Sia, ZY Fu, SH Mohd Rodhi, JHY Yee, K Qu… - International Journal of …, 2024 - mdpi.com
Adeno-associated viruses (AAVs) have emerged as promising tools for gene therapy due to
their safety and efficacy in delivering therapeutic genes or gene editing sequences to …
their safety and efficacy in delivering therapeutic genes or gene editing sequences to …
Light-Controlled Peptide Ligands for the Photoaffinity Purification of FLT3 and CD38
BD Moore, R Prodromou, GP Rusch… - ACS Applied …, 2025 - ACS Publications
The growth of biologics in modern medicine poses a pressing need for efficient process
technologies capable of delivering clinically relevant amounts of highly pure and active …
technologies capable of delivering clinically relevant amounts of highly pure and active …