[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

Research progress of disulfide bond based tumor microenvironment targeted drug delivery system

W Ma, X Wang, D Zhang, X Mu - International Journal of …, 2024 - Taylor & Francis
Cancer poses a significant threat to human life and health. Chemotherapy is currently one of
the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low …

[HTML][HTML] Exploring the Transformative Potential of Functionalized Mesoporous Silica in Enhancing Antioxidant Activity: A Comprehensive Review

A Budiman, A Rusdin, YW Wardhana, LE Puluhulawa… - Antioxidants, 2024 - mdpi.com
Antioxidants are essential for reducing oxidative stress, protecting cells from damage, and
supporting overall well-being. Functionalized mesoporous silica materials have garnered …

Guanidine functionalized porous SiO 2 as heterogeneous catalysts for microwave depolymerization of PET and PLA

É Casey, R Breen, G Pareras, A Rimola… - RSC …, 2024 - pubs.rsc.org
Chemical recycling is an important strategy to tackle the growing global problem of plastic
waste pollution. The development of metal-free catalysts for depolymerization of plastics is …

[HTML][HTML] Virus-like silica nanoparticles improve permeability of macromolecules across the blood–brain barrier in vitro

Y Feng, Y Cao, Z Qu, TI Janjua, A Popat - Pharmaceutics, 2023 - mdpi.com
The presence of the blood–brain barrier (BBB) limits the delivery of therapies into the brain.
There has been significant interest in overcoming the BBB for the effective delivery of …

[HTML][HTML] Establishing the Thermodynamic Cards of Dipine Models' Oxidative Metabolism on 21 Potential Elementary Steps

GB Shen, SH Gao, YW Jia, XQ Zhu, BC Qian - Molecules, 2024 - mdpi.com
Dipines are a type of important antihypertensive drug as L-calcium channel blockers, whose
core skeleton is the 1, 4-dihydropyridine structure. Since the dihydropyridine ring is a key …

Silica nanoparticles for brain cancer

Y Feng, Y Cao, R Singh, TI Janjua… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Brain cancer is a debilitating disease with a poor survival rate. There are
significant challenges for effective treatment due to the presence of the blood–brain barrier …

Hollow mesoporous silica nanoparticles for drug formulation and delivery: opportunities for cancer therapy

H Guo, X Zhao, Y Duan, J Shi - Colloids and Surfaces B: Biointerfaces, 2025 - Elsevier
The advantages of large surface area, high volume ratio, good biocompatibility, and
controllable surface functionalization make hollow mesoporous silica nanoparticles …

Functionalization of Silica Nanoparticles for Tailored Interactions with Intestinal Cells and Chemical Modulation of Paracellular Permeability

C Iriarte‐Mesa, J Bergen, K Danielyan, F Crudo… - Small …, 2025 - Wiley Online Library
The intestinal compartment confines the gut microbiome while enabling food passage and
absorption of active molecules. For the rational design of oral formulations aiming to …

[HTML][HTML] Harnessing silica nanoparticles grafted with ascorbic acid to alleviate oxidative stress and impaired brain activity in Rats

E Hamdi, S Hidouri, AB Muniz-Gonzalez… - Nano TransMed, 2025 - Elsevier
The brain has natural antioxidant defense systems, functioning through enzymes such as
superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase, which neutralize …