Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common
developmental disorders present in humans. Combined, they affect between 3 and 5% of …

Proper brain function requires stringent balance of excitatory and inhibitory synapse
formation during neural circuit assembly. Mutation of genes that normally sculpt and …

Neurexins are key adhesion proteins that coordinate extracellular and intracellular synaptic
components. Nonetheless, the low abundance of these multidomain proteins has …

Synapse formation and maturation requires bidirectional communication across the synaptic
cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe …

Synaptic function is crucially dependent on the spatial organization of the presynaptic and
postsynaptic apparatuses and the juxtaposition of both membrane compartments. This …

Neurexins are highly spliced transmembrane cell adhesion molecules that bind an array of
partners via their extracellular domains. However, much less is known about the signaling …

Neurodevelopmental disorders (NDDs) include a large number of conditions such as Fragile
X syndrome, autism spectrum disorders and Down syndrome, among others. They are …

During brain development, each neuron must find and synapse with the correct pre-and
postsynaptic partners. The complexity of these connections and the relatively large …

Neurexins are synaptic adhesion molecules that play diverse roles in synaptic development,
function, maintenance, and plasticity. Neurexin genes have been associated with changes …