Understanding functional effects of genetic variants is one of the key challenges in human
genetics, as much of disease-associated variation is located in non-coding regions with …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Biobanks often contain several phenotypes relevant to diseases such as major depressive
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …

Disease classification, or nosology, was historically driven by careful examination of clinical
features of patients. As technologies to measure and understand human phenotypes …

Heritable variation in gene expression forms a crucial bridge between genomic variation
and the biology of many traits. However, most expression quantitative trait loci (eQTLs) …

Principal component analysis (PCA) is widely used to control for population structure in
genome-wide association studies (GWAS). Top principal components (PCs) typically reflect …

Several bacteria in the gut microbiota have been shown to be associated with inflammatory
bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome …

Adipose tissue is an important endocrine organ with a role in many cardiometabolic
diseases. It is comprised of a heterogeneous collection of cell types that can differentially …

Background Molecular and cellular changes are intrinsic to aging and age-related diseases.
Prior cross-sectional studies have investigated the combined effects of age and genetics on …

Understanding the causal processes that contribute to disease onset and progression is
essential for develo** novel therapies. Although trans-acting expression quantitative trait …