Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …

Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …