[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …
first-choice drug used daily by approximately 150 million people. An accumulation of …
The long and short non-coding RNAs modulating EZH2 signaling in cancer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …
encoding proteins. However, they participate in developmental and biological processes …
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer
S Dong, S Liang, Z Cheng, X Zhang, L Luo, L Li… - Journal of Experimental …, 2022 - Springer
Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …
[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
The role of AMPK in cancer metabolism and its impact on the immunomodulation of the tumor microenvironment
CK Keerthana, TP Rayginia, SC Shifana… - Frontiers in …, 2023 - frontiersin.org
Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …
The metabolic mechanisms of breast cancer metastasis
L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …
A highly annotated database of genes associated with platinum resistance in cancer
Platinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …
to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant …
METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression
Background Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …
world, with a high likelihood of metastasis and a dismal prognosis. The reprogramming of …
NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy
Y Dai, Z Sun, H Zhao, D Qi, X Li, D Gao, M Li, Q Fan… - Biomaterials, 2021 - Elsevier
Photothermal therapy (PTT) is hampered by limited light penetration depth and cell
thermoresistance induced by over-expressed heat shock proteins (HSPs). Herein, we …
thermoresistance induced by over-expressed heat shock proteins (HSPs). Herein, we …