Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts …
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics …
disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics …
Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are
the second most abundant type of RNA in the cell. Advancement in deep-sequencing …
the second most abundant type of RNA in the cell. Advancement in deep-sequencing …
Immunophenoty** of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Although most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer …
Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection
AL Totura, A Whitmore, S Agnihothram, A Schäfer… - MBio, 2015 - Am Soc Microbiol
Toll-like receptors (TLRs) are sensors that recognize molecular patterns from viruses,
bacteria, and fungi to initiate innate immune responses to invading pathogens. The …
bacteria, and fungi to initiate innate immune responses to invading pathogens. The …
Large-scale microbiome data integration enables robust biomarker identification
L **ao, F Zhang, F Zhao - Nature Computational Science, 2022 - nature.com
The close association between gut microbiota dysbiosis and human diseases is being
increasingly recognized. However, contradictory results are frequently reported, as …
increasingly recognized. However, contradictory results are frequently reported, as …
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
Background Representing biological networks as graphs is a powerful approach to reveal
underlying patterns, signatures, and critical components from high-throughput biomolecular …
underlying patterns, signatures, and critical components from high-throughput biomolecular …
SARS-CoV-2 switches 'on'MAPK and NFκB signaling via the reduction of nuclear DUSP1 and DUSP5 expression
S Goel, F Saheb Sharif-Askari… - Frontiers in …, 2021 - frontiersin.org
Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many
cellular processes and are essential for immune cells function. Their activity is controlled by …
cellular processes and are essential for immune cells function. Their activity is controlled by …
Recent aspects on the pathogenesis mechanism, animal models and novel therapeutic interventions for Middle East respiratory syndrome coronavirus infections
S Skariyachan, SB Challapilli, S Packirisamy… - Frontiers in …, 2019 - frontiersin.org
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging zoonotic virus
considered as one of the major public threat with a total number of 2 298 laboratory …
considered as one of the major public threat with a total number of 2 298 laboratory …
Interferon-induced transmembrane protein (IFITM3) is upregulated explicitly in SARS-CoV-2 infected lung epithelial cells
Current guidelines for COVID-19 management recommend the utilization of various
repurposed drugs. Despite ongoing research toward the development of a vaccine against …
repurposed drugs. Despite ongoing research toward the development of a vaccine against …