Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

The increasing life expectancy has led to a higher incidence of age-related
neurodegenerative conditions. Within this framework, neuroinflammation emerges as a …

Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent 2 of the largest sources
of death and disability in the United States. Recent studies have identified TBI as a potential …

Microglia, the resident immune cells of the brain, are increasingly implicated in the
regulation of brain health and disease. Microglia perform multiple functions in the central …

Background Parkinson's disease (PD) is the second most common neurodegenerative
disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation …

DNA damage and neurodegenerative disorders are intimately linked but the underlying
mechanism remains elusive. Here, we show that persistent DNA lesions in tissue-resident …

Neuroprotection is a proactive approach to safeguarding the nervous system, including the
brain, spinal cord, and peripheral nerves, by preventing or limiting damage to nerve cells …

Objective Because the role of white matter (WM) degenerating microglia (DM) in
remyelination failure is unclear, we sought to define the core features of this novel …