Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …

Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance

MJ Shepherd, T Fu, NE Harrington, A Kottara… - Nature Reviews …, 2024 - nature.com
The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …

PcdA promotes orthogonal division plane selection in Staphylococcus aureus

F Ramos-León, BR Anjuwon-Foster… - Nature …, 2024 - nature.com
The bacterial pathogen, Staphylococcus aureus, grows by dividing in two alternating
orthogonal planes. How these cell division planes are positioned correctly is not known …

Within-host evolution of bacterial pathogens in acute and chronic infection

JP Dekker - Annual Review of Pathology: Mechanisms of …, 2024 - annualreviews.org
Bacterial pathogens undergo remarkable adaptive change in response to the selective
forces they encounter during host colonization and infection. Studies performed over the …

Genomic epidemiology of Staphylococcus aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

S Di Gregorio, J Vielma, MS Haim… - Microbial …, 2023 - microbiologyresearch.org
Staphylococcus aureus remains one of the leading causes of infections worldwide and a
common cause of bacteraemia. However, studies documenting the epidemiology of S …

Detecting bacterial adaptation within individual microbiomes

TD Lieberman - … Transactions of the Royal Society B, 2022 - royalsocietypublishing.org
The human microbiome harbours a large capacity for within-person adaptive mutations.
Commensal bacterial strains can stably colonize a person for decades, and billions of …

Antigenic operon fragmentation and diversification mechanism in Bacteroidota impacts gut metagenomics and pathobionts in Crohn's disease microlesions

NC Bank, V Singh, B McCourt, A Burberry… - Gut …, 2024 - Taylor & Francis
ABSTRACT Comensal Bacteroidota (Bacteroidota) and Enterobacteriacea are often linked
to gut inflammation. However, the causes for variability of pro-inflammatory surface antigens …

The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant Staphylococcus aureus

TK Nielsen, IB Petersen, L Xu, MD Barbuti… - Antimicrobial Agents …, 2024 - journals.asm.org
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a leading
cause of mortality worldwide. MRSA has acquired resistance to next-generation β-lactam …

YjbH contributes to Staphylococcus aureus skin pathology and immune response through Agr-mediated α-toxin regulation

AKG McReynolds, EA Pagella, MJ Ridder, O Rippee… - Virulence, 2024 - Taylor & Francis
Staphylococcus aureus is the most common cause of skin and soft tissue infections (SSTIs)
with Methicillin-Resistant S. aureus (MRSA) strains being a major contributor in both …

[HTML][HTML] Diverse genetic conflicts mediated by molecular mimicry and computational approaches to detect them

SL Russell, G Penunuri, C Condon - Seminars in Cell & Developmental …, 2025 - Elsevier
In genetic conflicts between intergenomic and selfish elements, driver and killer elements
achieve biased survival, replication, or transmission over sensitive and targeted elements …