Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …