Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …

Musculoskeletal injuries and disorders are the leading cause of physical disability
worldwide and a considerable socioeconomic burden. The lack of effective therapies has …

Osteoarthritis (OA) is a chronic, debilitating disease that substantially impairs the quality of
life of affected individuals. The underlying mechanisms of OA are diverse and are becoming …

Despite all improvements in rheumatoid arthritis, we are still not able to prevent or cure the
disease. Diagnostic delays due to lack of access to a specialist and costly therapies are still …

Immunoengineering continues to revolutionize healthcare, generating new approaches for
treating previously intractable diseases, particularly in regard to cancer immunotherapy. In …

The medical risks of spaceflight are amplified as humans venture into longer-duration and
greater-distance deep space voyages. During space missions, astronauts face the extremes …

'Mechanogenetics,'a new field at the convergence of mechanobiology and synthetic biology,
presents an innovative strategy to treat, repair, or restore diseased cells and tissues by …

Osteoarthritis is a complex degenerative disease that affects the entire joint tissue. Currently,
non-surgical treatments for osteoarthritis focus on relieving pain. While end-stage …

Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In
addition to their multipotency, stem cells possess immunomodulatory effects that can …