Abstract mRNA surveillance pathways are essential for accurate gene expression and to
maintain translation homeostasis, ensuring the production of fully functional proteins. Future …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic
information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical …

The mammalian target of rapamycin (mTOR) is an evolutionally conserved kinase which
exists in two distinct structural and functional complexes, mTOR complex 1 (mTORC1) and …

Mammalian target of rapamycin (mTOR) is a member of the phosphatidylinositol 3-kinase-
related kinase (PIKK) family and is a major regulator of translation, cell growth, and …

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and
degrades mRNAs containing premature termination codons (PTCs). SMG-1-mediated Upf1 …

The metabolism of glucose and glutamine, primary carbon sources utilized by mitochondria
to generate energy and macromolecules for cell growth, is directly regulated by mTORC1 …

Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …

TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-
related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that …

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS).
However, the epigenetic networks underlying the maintenance of oncogenic signaling and …