Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Fluorine-18 is one of the most widely used radionuclides for the production of
radiopharmaceuticals for positron emission tomography (PET). The radiolabeling methods …

CF2H groups are unique due to the combination of their lipophilic and hydrogen bonding
properties. The strength of H-bonding is determined by the group to which it is appended …

The use of kinase-directed precision medicine has been heavily pursued since the
discovery and development of imatinib. Annually, it is estimated that around∼ 20 000 new …

Conspectus Computational methods for docking small molecules to proteins are prominent
in drug discovery. There are hundreds, if not thousands, of documented examples and …

Changes in expression and dysfunctional signaling of TrkA/B/C receptors and oncogenic Trk
fusion proteins are found in neurological diseases and cancers. Here, we describe the …

Over the last 20 years, intensive investigation and multiple clinical successes targeting
protein kinases, mostly for cancer treatment, have identified small molecule kinase inhibitors …

The proto-oncogenes NTRK1/2/3 encode the tropomyosin receptor kinases TrkA/B/C which
play pivotal roles in neurobiology and cancer. We describe herein the discovery of [11C]-(R) …

Sepsis can induce acute and chronic changes in the central nervous system termed sepsis-
associated encephalopathy (SAE). Not only cognitive deficits but also anxiety, depression …

Soft tissue trauma can cause immune system disturbance and neuropathological invasion,
resulting in heterotopic ossification (HO) due to aberrant chondrogenic differentiation of …