Genetics of diabetes mellitus and diabetes complications
Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …
Genetic susceptibility to chronic kidney disease–some more pieces for the heritability puzzle
Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …
prevalence partly driven by aging population structure. Both genomic and environmental …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
Discovery and prioritization of variants and genes for kidney function in> 1.2 million individuals
Genes underneath signals from genome-wide association studies (GWAS) for kidney
function are promising targets for functional studies, but prioritizing variants and genes is …
function are promising targets for functional studies, but prioritizing variants and genes is …
A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
Genome-wide association studies (GWAS) have identified thousands of genomic regions
affecting complex diseases. The next challenge is to elucidate the causal genes and …
affecting complex diseases. The next challenge is to elucidate the causal genes and …
Genome-wide association study of diabetic kidney disease highlights biology involved in glomerular basement membrane collagen
Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …
[HTML][HTML] Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development
The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …