Microscale thermophoresis as a powerful growing analytical technique for the investigation of biomolecular interaction and the determination of binding parameters
The in vitro panel of technologies to address biomolecular interactions are in play, however
microscale thermophoresis is continuously increasing in use to represent a key player in this …
microscale thermophoresis is continuously increasing in use to represent a key player in this …
Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update
A Rajendran, K Palaniyandi - Current Microbiology, 2022 - Springer
Pyrazinamide (PZA) has remained a keystone of tuberculosis (TB) therapy, and it possesses
high imperative sterilizing action that can facilitate reduction in the present chemotherapy …
high imperative sterilizing action that can facilitate reduction in the present chemotherapy …
Emerging insight of whole genome sequencing coupled with protein structure prediction into the pyrazinamide-resistance signature of Mycobacterium tuberculosis
CK Huang, MC Yu, CS Hung, JC Lin - International Journal of Antimicrobial …, 2024 - Elsevier
Pyrazinamide (PZA) is considered to be a pivotal drug to shorten the treatment of both drug-
susceptible and drug-resistant tuberculosis, but its use is challenged by the reliability of drug …
susceptible and drug-resistant tuberculosis, but its use is challenged by the reliability of drug …
Overcoming the challenges of pyrazinamide susceptibility testing in clinical Mycobacterium tuberculosis isolates
Pyrazinamide (PZA) is one of the first-line agents used for the treatment of tuberculosis.
However, current phenotypic PZA susceptibility testing in the Bactec MGIT 960 system is …
However, current phenotypic PZA susceptibility testing in the Bactec MGIT 960 system is …
Association between fatty acid metabolism gene mutations and Mycobacterium tuberculosis transmission revealed by whole genome sequencing
Y Li, X Kong, Y Li, N Tao, T Wang, Y Li, Y Hou, X Zhu… - BMC microbiology, 2023 - Springer
Background Fatty acid metabolism greatly promotes the virulence and pathogenicity of
Mycobacterium tuberculosis (M. tb). However, the regulatory mechanism of fatty acid …
Mycobacterium tuberculosis (M. tb). However, the regulatory mechanism of fatty acid …
Trans-Translation Is an Appealing Target for the Development of New Antimicrobial Compounds
R Campos-Silva, G D'Urso, O Delalande, E Giudice… - Microorganisms, 2021 - mdpi.com
Because of the ever-increasing multidrug resistance in microorganisms, it is crucial that we
find and develop new antibiotics, especially molecules with different targets and …
find and develop new antibiotics, especially molecules with different targets and …
The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China
N Wang, F Meng, L Deng, L Wu, Y Yang… - Emerging Microbes & …, 2024 - Taylor & Francis
This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in
Southern China over 11 years (2012–2022) and evaluates the mutation characteristics of …
Southern China over 11 years (2012–2022) and evaluates the mutation characteristics of …
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents
Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and
morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen …
morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen …
Synthesis, kinetics, structure-activity relationship and in silico ADME studies of new diazenyl azo-phenol derivatives against urease, SARS-CoV-2 main protease …
In the present study, a new series of diazenyl azo-phenol derivatives (TC-1 to TC-8) have
been synthesized via diazo-coupling approach between substituted aromatic amines and …
been synthesized via diazo-coupling approach between substituted aromatic amines and …
The Structural and Molecular Mechanisms of Mycobacterium tuberculosis Translational Elongation Factor Proteins
N Fang, L Wu, S Duan, J Li - Molecules, 2024 - mdpi.com
Targeting translation factor proteins holds promise for develo** innovative anti-
tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at …
tuberculosis drugs. During protein translation, many factors cause ribosomes to stall at …