The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Increasing evidence suggests that the failure of clinical antidepressants may be related with
neuroinflammation. The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) …

Real‐time imaging of programmed cancer cell death (PCD) is imperative to monitor cancer
therapeutic efficacy and tailor therapeutic regimens; however, specific in vivo detection of …

Previous studies have demonstrated a bidirectional relationship between inflammation and
depression. Activation of the nucleotide-binding oligomerization domain, leucine-rich repeat …

Post-traumatic epilepsy (PTE) is one of the most debilitating consequences of traumatic
brain injury (TBI) and is one of the most drug-resistant forms of epilepsy. Novel therapeutic …

Overactivated NLRP3 inflammasome has been shown to associate with an increasing
number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1 …

Neuroinflammation is an adaptive response of the central nervous system to diverse
potentially injurious stimuli, which is closely associated with neurodegeneration and …

Postoperative cognitive dysfunction (POCD) is a cluster of cognitive problems that may arise
after surgery. POCD symptoms include memory loss, focus inattention, and communication …

The NOD-like receptor (NLR) family pyrin-domain-containing 3 (NLRP3) inflammasome, an
essential component of the innate immune system, has been emerging as a viable drug …

Introduction Inflammasome complexes, especially NLRP3, have gained great attention as a
potential therapeutic target in mood disorders. NLRP3 triggers a caspase 1-dependent …