Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

The well-organized cerebellar structures and neuronal networks are likely crucial for their
functions in motor coordination, motor learning, cognition, and emotion. Such cerebellar …

Abstract Spinocerebellar ataxia type 6 (SCA6) is a rare disease that is characterized by
cerebellar dysfunction. Patients have progressive motor coordination impairment, and …

Abstract Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that
manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients …

In degenerative neurological disorders such as Parkinson's disease, a convergence of
widely varying insults results in a loss of dopaminergic neurons and, thus, the motor …

A molecular and functional link between neurotrophin signaling and cerebellar foliation is
lacking. Here we show that constitutive knockout of two homologous genes encoding the …

The spatial organization of a neuronal circuit is critically important for its function since the
location of neurons is often associated with function. In the cerebellum, the major output of …

Polyglutamine spinocerebellar ataxias (polyQ SCAs) represent the most prevalent subtype
of SCAs. The primary pathogenic mechanism is believed to be the gain-of-function …

Simple Summary Patients suffering from ataxia disorders show symptoms of incoordination
often attributed to cerebellar dysfunction and eventual degeneration of Purkinje cells (PCs) …