Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …

Peptides hold great promise in proteomics, diagnostics and drug discovery. While natural
peptides continue to be of key importance, chemically modified unnatural peptides have …

Carboxylic acids are highly abundant in bioactive molecules. In this study, we describe the
late-stage β-C (sp3)–H deuteration of free carboxylic acids. On the basis of the finding that C …

The first example of free amine γ-C (sp3)–H fluorination is realized using 2-
hydroxynicotinaldehyde as the transient directing group. A wide range of cyclohexyl and …

In the past decade, selective C–C and C-heteroatom bond construction through palladium-
catalyzed direct C–H bond functionalization has been extensively studied by employing a …

Over the years, silver salts have become an integral part of palladium-catalyzed C–H
functionalization. Although most of the research works highlight the role of Ag (I) complexes …

Illustrated herein is a Pd (II)-catalyzed direct difunctionalization of two C (sp3)–H bonds of
aliphatic carboxylic acid derivatives by bifunctional reagents (BFRs) of the 2-iodobenzoic …

Difunctionalized cyclobutanes are an emerging scaffold in medicinal chemistry that can
confer beneficial pharmacological properties to small‐molecule drug candidates. However …

Scaling relations and volcano plots are widely used in heterogeneous catalysis. In this
Perspective, we discuss the prospects and challenges associated with the application of …

Migratory insertions of alkenes into metal–carbon (M–C) bonds are elementary steps in
diverse catalytic processes. In the present work, a radical-type migratory insertion that …