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[HTML][HTML] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
Quiescence of adult mammalian neural stem cells: a highly regulated rest
Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …
Glucocorticoids as mediators of adverse outcomes of prenatal stress
A number of prenatal experiences are associated with adverse outcomes after birth, ranging
from cardiovascular problems to psychiatric disease. Prenatal stress is associated with …
from cardiovascular problems to psychiatric disease. Prenatal stress is associated with …
[HTML][HTML] The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …
array of diverse biological processes including glial function, metabolism, peripheral …
[HTML][HTML] What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons
The hippocampus exerts inhibitory feedback on the release of glucocorticoids. Because the
major hippocampal efferent projections are excitatory, it has been hypothesized that this …
major hippocampal efferent projections are excitatory, it has been hypothesized that this …
[HTML][HTML] Adult neurogenesis, human after all (again): Classic, optimized, and future approaches
In this perspective article, we reflect on the recent debate about the existence of human
neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and …
neurogenesis and discuss direct, and also indirect, support for the ongoing formation, and …
Circadian regulation of adult stem cell homeostasis and aging
The circadian clock temporally organizes cellular physiology throughout the day, allowing
daily environmental changes to be anticipated and potentially harmful physiologic …
daily environmental changes to be anticipated and potentially harmful physiologic …
Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overload
Exposure to stress during early life may alter the developmental trajectory of an animal by a
mechanism known as adaptive plasticity. For example, to enhance reproductive success in …
mechanism known as adaptive plasticity. For example, to enhance reproductive success in …