Microglia are brain-resident macrophages that contribute to central nervous system (CNS)
development, maturation, and preservation. Here, we examine the consequences of …

Signals from the surrounding niche drive proliferation and suppress differentiation of
intestinal stem cells (ISCs) at the bottom of intestinal crypts. Among sub-epithelial support …

Background Xenotransplantation of genetically engineered porcine organs has the potential
to address the challenge of organ donor shortage. Two cases of porcine-to-human kidney …

Bacterial symbionts are critical members of many marine sponge holobionts. Some sponge-
associated bacterial lineages, such as Poribacteria, sponge-associated unclassified lineage …

Background Lesion network map** (LNM) is a popular framework to assess clinical
syndromes following brain injury. The classical approach involves embedding lesions from …

Staphylococcus aureus is an opportunistic pathogen and a leading cause of morbidity and
mortality worldwide. Genomic-based surveillance has greatly improved our ability to track …

Blocking the cell cycle is a promising avenue for cancer therapy, with Cyclin-Dependent
Kinase 2 (CDK2) emerging as a key target. However, in multiple cell types, CDK4/6 activity …

The provenance of copper is a major focus in archaeometallurgical studies of Bronze Age
China. Despite a large dataset of lead isotopes and trace elements accumulated over the …

The shape of a cell both influences and is influenced by its fate. However, quantitative
studies of cell shape in living, develo** organisms have been limited in dimension and …