Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge
Interleukin-11 (IL-11) is a profibrotic cytokine essential for the differentiation of fibroblasts
into collagen-secreting, actin alpha 2, smooth muscle–positive (ACTA2+) myofibroblasts …
into collagen-secreting, actin alpha 2, smooth muscle–positive (ACTA2+) myofibroblasts …
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
H Zhang, X You, X Wang, L Cui… - Proceedings of the …, 2021 - National Acad Sciences
Intracellular delivery of messenger RNA (mRNA)-based cancer vaccine has shown great
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …
potential to elicit antitumor immunity. To achieve robust antitumor efficacy, mRNA encoding …
Strategies, design, and chemistry in siRNA delivery systems
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …
Stimuli-responsive therapeutic metallodrugs
The success of platinum-based anticancer agents has motivated the exploration of novel
metal-based drugs for several decades, whereas problems such as drug-resistance and …
metal-based drugs for several decades, whereas problems such as drug-resistance and …
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Increasing clinical evidence has demonstrated that the deletion or mutation of tumor
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
suppressor genes such as the gene-encoding phosphatase and tensin homolog deleted on …
Cancer nanomedicine: progress, challenges and opportunities
The intrinsic limits of conventional cancer therapies prompted the development and
application of various nanotechnologies for more effective and safer cancer treatment …
application of various nanotechnologies for more effective and safer cancer treatment …
Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice
Synthetic mRNA represents an exciting cancer vaccine technology for the implementation of
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …
effective cancer immunotherapy. However, inefficient in vivo mRNA delivery along with a …
Enhanced cisplatin chemotherapy by iron oxide nanocarrier-mediated generation of highly toxic reactive oxygen species
Reactive oxygen species (ROS) plays a key role in therapeutic effects as well as side effects
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …
of platinum drugs. Cisplatin mediates activation of nicotinamide adenine dinucleotide …