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Hair cell toxicology: with the help of a little fish
Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …
suffering them, especially when they appear in children. Their ultimate cause is frequently …
Cilia in the develo** zebrafish ear
TT Whitfield - … Transactions of the Royal Society B, 2020 - royalsocietypublishing.org
The inner ear, which mediates the senses of hearing and balance, derives from a simple
ectodermal vesicle in the vertebrate embryo. In the zebrafish, the otic placode and vesicle …
ectodermal vesicle in the vertebrate embryo. In the zebrafish, the otic placode and vesicle …
Distinct progenitor populations mediate regeneration in the zebrafish lateral line
Mechanosensory hair cells of the zebrafish lateral line regenerate rapidly following damage.
These renewed hair cells arise from the proliferation of surrounding support cells, which …
These renewed hair cells arise from the proliferation of surrounding support cells, which …
The role of cilia in the development, survival, and regeneration of hair cells
H Boldizar, A Friedman, T Stanley, M Padilla… - Biology …, 2024 - journals.biologists.com
Mutations impacting cilia genes lead to a class of human diseases known as ciliopathies.
This is due to the role of cilia in the development, survival, and regeneration of many cell …
This is due to the role of cilia in the development, survival, and regeneration of many cell …
In vivo screening for toxicity-modulating drug interactions identifies antagonism that protects against ototoxicity in zebrafish
E Bustad, E Mudrock, EM Nilles, A Mcquate… - Frontiers in …, 2024 - frontiersin.org
Introduction: Ototoxicity is a debilitating side effect of over 150 medications with diverse
mechanisms of action, many of which could be taken concurrently to treat multiple …
mechanisms of action, many of which could be taken concurrently to treat multiple …
alms1 mutant zebrafish do not show hair cell phenotypes seen in other cilia mutants
L Parkinson, TM Stawicki - PLoS One, 2021 - journals.plos.org
Multiple cilia-associated genes have been shown to affect hair cells in zebrafish (Danio
rerio), including the human deafness gene dcdc2, the radial spoke gene rsph9, and multiple …
rerio), including the human deafness gene dcdc2, the radial spoke gene rsph9, and multiple …