Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

The ability to rapidly restore the integrity of a broken skin barrier is critical and is the ultimate
goal of therapies for hard-to-heal-ulcers. Unfortunately effective treatments to enhance …

The microbiota plays a fundamental role in the induction, education, and function of the host
immune system. In return, the host immune system has evolved multiple means by which to …

Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Background Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of
the immune system and leads to the photoaging state which is reminiscent of chronological …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

The maintenance of tissue homeostasis is critically dependent on the function of tissue-
resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs) …

Tissue-resident memory T (Trm) cells form a heterogeneous population that provides
localized protection against pathogens. Here, we identify CD49a as a marker that …