The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
PPARγ and the global map of adipogenesis and beyond
MI Lefterova, AK Haakonsson, MA Lazar… - Trends in Endocrinology …, 2014 - cell.com
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
Structure of the human Mediator-bound transcription preinitiation complex
Eukaryotic transcription requires the assembly of a multisubunit preinitiation complex (PIC)
composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator …
composed of RNA polymerase II (Pol II) and the general transcription factors. The coactivator …
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
S Malik, RG Roeder - Nature Reviews Genetics, 2010 - nature.com
The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of
protein-coding genes. In metazoan cells, multiple pathways that are responsible for …
protein-coding genes. In metazoan cells, multiple pathways that are responsible for …
Transcriptional and epigenomic regulation of adipogenesis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
PPARs: fatty acid sensors controlling metabolism
L la Cour Poulsen, M Siersbæk, S Mandrup - Seminars in cell & …, 2012 - Elsevier
The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …
The Mediator complex and transcription regulation
ZC Poss, CC Ebmeier, DJ Taatjes - Critical reviews in biochemistry …, 2013 - Taylor & Francis
The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …
[HTML][HTML] PPARγ in adipocyte differentiation and metabolism–novel insights from genome-wide studies
R Siersbæk, R Nielsen, S Mandrup - FEBS letters, 2010 - Elsevier
Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which
PPARγ and members of the C/EBP family are key players. Here we review the roles of …
PPARγ and members of the C/EBP family are key players. Here we review the roles of …
Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading
MS Madsen, R Siersbæk, M Boergesen… - … and cellular biology, 2014 - Am Soc Microbiol
Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …
Function and regulation of the Mediator complex
RC Conaway, JW Conaway - Current opinion in genetics & development, 2011 - Elsevier
Over the past few years, advances in biochemical and genetic studies of the structure and
function of the Mediator complex have shed new light on its subunit architecture and its …
function of the Mediator complex have shed new light on its subunit architecture and its …