Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment

M Xu, S Li - Cancer Letters, 2023 - Elsevier
Melanoma, the most aggressive form of cutaneous malignancy arising from melanocytes, is
frequently characterized by metastasis. Despite considerable progress in melanoma …

A new era of cancer phototherapy: mechanisms and applications

Y Wang, K Ma, M Kang, D Yan, N Niu, S Yan… - Chemical Society …, 2024 - pubs.rsc.org
The past decades have witnessed great strides in phototherapy as an experimental option
or regulation-approved treatment in numerous cancer indications. Of particular interest is …

An autocatalytic multicomponent DNAzyme nanomachine for tumor-specific photothermal therapy sensitization in pancreatic cancer

J Yan, X Ma, D Liang, M Ran, D Zheng, X Chen… - Nature …, 2023 - nature.com
Multicomponent deoxyribozymes (MNAzymes) have great potential in gene therapy, but
their ability to recognize disease tissue and further achieve synergistic gene regulation has …

Aggregation induced emission dynamic chiral europium (III) complexes with excellent circularly polarized luminescence and smart sensors

YL Li, HL Wang, ZH Zhu, YF Wang, FP Liang… - Nature …, 2024 - nature.com
The synthesis of dynamic chiral lanthanide complex emitters has always been difficult.
Herein, we report three pairs of dynamic chiral EuIII complex emitters (R/S-Eu-R-1, R …

Bioorthogonal guided activation of cGAS‐STING by AIE photosensitizer nanoparticles for targeted tumor therapy and imaging

M Cui, D Tang, B Wang, H Zhang, G Liang… - Advanced …, 2023 - Wiley Online Library
Photodynamic therapy (PDT) and photothermal therapy (PTT) leverage reactive oxygen
species (ROS) and control local hyperthermia by photosensitizer to perturb intracellular …

Genetically edited cascade nanozymes for cancer immunotherapy

J Zhang, Y Pan, L Liu, Y Xu, C Zhao, W Liu, L Rao - ACS nano, 2024 - ACS Publications
Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its
therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and …

An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment

S Song, Y Zhao, M Kang, F Zhang, Q Wu… - Advanced …, 2024 - Wiley Online Library
One‐for‐all phototheranostics, referring to a single component simultaneously exhibiting
multiple optical imaging and therapeutic modalities, has attracted significant attention due to …

Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy

K Wang, X Zhang, H Ye, X Wang, Z Fan, Q Lu… - Nature …, 2023 - nature.com
Abstract Cytokine therapy, involving interleukin-15 (IL-15), is a promising strategy for cancer
immunotherapy. However, clinical application has been limited due to severe toxicity and …

Gas-amplified metalloimmunotherapy with dual activation of pyroptosis and the STING pathway for remodeling the immunosuppressive cervical cancer …

L Liu, H Lei, G Hou, L Zhang, Y Chen, Y Lu, Z Pei… - ACS …, 2024 - ACS Publications
The immunosuppressive microenvironment of cervical cancer significantly hampers the
effectiveness of immunotherapy. Herein, PEGylated manganese-doped calcium sulfide …

Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron–Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer

G Li, S Wu, J Liu, K Wang, X Chen, H Liu - Advanced Materials, 2024 - Wiley Online Library
Sonodynamic therapy (SDT) is applied to bladder cancer (BC) given its advantages of high
depth of tissue penetration and nontoxicity due to the unique anatomical location of the …