Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

An increasing body of evidence indicates that transcription and splicing are coupled, and it
is accepted that chromatin organization regulates transcription. Little is known about the …

H3K27 methylation mediated by the histone methyltransferase complex PRC2 is critical for
transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X …

Abstract Polycomb group (PcG) and Trithorax group (TrxG) genes encode important
regulators of development and differentiation in metazoans. These two groups of genes …

The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse
diseases and commonly overexpressed in multiple myeloma due to a recurrent t (4; 14) …

Understanding the function of histone modifications across inducible genes in mammalian
cells requires quantitative, comparative analysis of their fate during gene activation and …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Most multi-cellular organisms adopt a specific gene expression pattern during cellular
differentiation. Once established, this pattern is frequently maintained over several cell …