Polysialylation and disease

C Sato, K Kitajima - Molecular Aspects of Medicine, 2021 - Elsevier
Polysialic acid (polySia, PSA) is a unique constituent of the glycocalyx on the surface of
bacterial and vertebrate cells. In vertebrates, its biosynthesis is highly regulated, not only in …

Synthetically defined glycoprotein vaccines: current status and future directions

R Adamo, A Nilo, B Castagner, O Boutureira, F Berti… - Chemical …, 2013 - pubs.rsc.org
Primary examples in vaccine design have shown good levels of carbohydrate-specific
antibody generation when raised using extracted or fully synthetic capsular polysaccharide …

The role of fluorine in glycomimetic drug design

R Hevey - Chemistry–A European Journal, 2021 - Wiley Online Library
Glycans are well established to play important roles at various stages of infection and
disease, and ways to modulate these interactions have been sought as novel therapies. The …

Disialic, oligosialic and polysialic acids: distribution, functions and related disease

C Sato, K Kitajima - The journal of biochemistry, 2013 - academic.oup.com
Sialic acids (Sia) are involved in many biological activities and frequently exist as monosialyl
residues at the non-reducing terminal end of glycoconjugates. Occasionally, polymerized …

Efficacy, safety, and immunogenicity of a meningococcal group B (15: P1. 3) outer membrane protein vaccine in Iquique, Chile

J Boslego, J Garcia, C Cruz, W Zollinger, B Brandt… - Vaccine, 1995 - Elsevier
A meningococcal group B (15: P1. 3) outer membrane protein vaccine was tested for efficacy
in a randomized, double-blind controlled study in Iquique, Chile. A total of 40 811 …

Development of vaccines against meningococcal disease

L Jódar, IM Feavers, D Salisbury, DM Granoff - The Lancet, 2002 - thelancet.com
Neisseria meningitidis is a major cause of bacterial meningitis and sepsis. Polysaccharide–
protein conjugate vaccines for prevention of group C disease have been licensed in Europe …

Metabolic Glycoengineering with N‐Acyl Side Chain Modified Mannosamines

PR Wratil, R Horstkorte… - Angewandte Chemie …, 2016 - Wiley Online Library
In metabolic glycoengineering (MGE), cells or animals are treated with unnatural derivatives
of monosaccharides. After entering the cytosol, these sugar analogues are metabolized and …

Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine

I Claassen, J Meylis, P van der Ley, C Peeters, H Brons… - Vaccine, 1996 - Elsevier
An experimental serogroup B meningococcal vaccine was prepared from two genetically
engineered strains; each expressing three different class 1 outer membrane proteins …

Meningococcal vaccines: current status and emerging strategies

PC McCarthy, A Sharyan, L Sheikhi Moghaddam - Vaccines, 2018 - mdpi.com
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis
is a public health burden to both developed and develo** countries throughout the world …

[BUCH][B] Practical aspects of hyaluronan based medical products

JW Kuo - 2005 - taylorfrancis.com
The ballooning body of research devoted to hyaluronan (HA) reflects its enormous potential
for various medical applications. There have been many successes of varying degrees in …