Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

Paclitaxel (PTX) is an effective anticancer chemical with a broad spectrum that was primarily
obtained from a curative shrub, specifically the bark of Taxus brevifolia tree. It belongs to a …

Actin cytoskeleton dynamics are essential regulatory processes in muscle development,
growth, and regeneration due to their modulation of mechanotransduction, cell proliferation …

KANK1 is expressed in epithelial cells and connects focal adhesions with the adjacent
cortical microtubule stabilizing complex. Although KANK1 was shown to suppress cancer …

Simple Summary Cells can sense their physical environment, or extracellular matrix (ECM),
in a process called 'mechanosensing'. They do this via adhesion sites which allow them to …

Prostate cancer is a heterogeneous disease, and one of the main obstacles in its
management is the inability to foresee its course. Therefore, novel biomarkers are needed …

G-quadruplexes (G4s) are atypical nucleic acid structures involved in basic human
biological processes and are regulated by small molecules. To date, pyridostatin and its …

The mortality rate linked with nephrotic syndrome (NS) is quite high. The renal tubular injury
influences the response of NS patients to steroid treatment. KN motif and ankyrin repeat …

The KN Motif and AnKyrin Repeat Domain 1 (KANK1) is proposed as a tumour suppressor
gene, as its expression is reduced or absent in several types of tumour tissue, and over …

Abstract Background Focal adhesions (FAs) are integrin-containing, multi-protein structures
that link intracellular actin to the extracellular matrix and trigger multiple signaling pathways …