Targeting microglial α-synuclein/TLRs/NF-kappaB/NLRP3 inflammasome axis in Parkinson's disease
Y Li, Y **a, S Yin, F Wan, J Hu, L Kou, Y Sun… - Frontiers in …, 2021 - frontiersin.org
According to emerging studies, the excessive activation of microglia and the subsequent
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
release of pro-inflammatory cytokines play important roles in the pathogenesis and …
Alpha-synuclein aggregation in Parkinson's disease
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …
Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson's disease
Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from
green tea extract, possesses versatile bioactivities that can combat many diseases. During …
green tea extract, possesses versatile bioactivities that can combat many diseases. During …
Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders
S Banerjee, U Anand, S Ghosh, D Ray… - Phytotherapy …, 2021 - Wiley Online Library
From ancient history, complementary and alternative medicines have played a significant
role as holistic therapeutic treatments of various human diseases including cancer, diabetes …
role as holistic therapeutic treatments of various human diseases including cancer, diabetes …
Natural phytochemicals as novel therapeutic strategies to prevent and treat Parkinson's disease: current knowledge and future perspectives
Parkinson's disease (PD) is the second‐most common neurodegenerative chronic disease
affecting both cognitive performance and motor functions in aged people. Yet despite the …
affecting both cognitive performance and motor functions in aged people. Yet despite the …
Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
Microglia-targeting nanotherapeutics for neurodegenerative diseases
Advances in nanotechnology have enabled the design of nanotherapeutic platforms that
could address the challenges of targeted delivery of active therapeutic agents to the central …
could address the challenges of targeted delivery of active therapeutic agents to the central …
Alpha-synuclein targeting therapeutics for Parkinson's disease and related synucleinopathies
α-Synuclein (asyn) is a key pathogenetic factor in a group of neurodegenerative diseases
generically known as synucleinopathies, including Parkinson's disease (PD), dementia with …
generically known as synucleinopathies, including Parkinson's disease (PD), dementia with …
Conifers phytochemicals: A valuable forest with therapeutic potential
Conifers have long been recognized for their therapeutic potential in different disorders.
Alkaloids, terpenes and polyphenols are the most abundant naturally occurring …
Alkaloids, terpenes and polyphenols are the most abundant naturally occurring …
Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease
Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …