Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

The impermeable barrier of solid tumors due to the complexity of their components limits the
treatment effect of nanomedicine and hinders its clinical translation. Several methods are …

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …

Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …

Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …

Background Triple-negative breast cancers (TNBCs), which lack receptors for estrogen,
progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive …

Nanoparticle drug formulations have been extensively investigated, developed, and in some
cases, approved by the Food and Drug Administration (FDA). Synergistic combinations of …

Recent advances in research on cancer have led to understand the pathogenesis of cancer
and development of new anticancer drugs. Despite of these advancements, many tumors …

The prominent role of CD44 in tumor cell signaling together with its establishment as a
cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC …