Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Exosome-based delivery strategies for tumor therapy: an update on modification, loading, and clinical application

Q Yang, S Li, H Ou, Y Zhang, G Zhu, S Li… - Journal of …, 2024 - Springer
Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …

[HTML][HTML] Extracellular vesicles in nanomedicine and regenerative medicine: a review over the last decade

S Moghassemi, A Dadashzadeh, MJ Sousa, H Vlieghe… - Bioactive materials, 2024 - Elsevier
Small extracellular vesicles (sEVs) are known to be secreted by a vast majority of cells.
These sEVs, specifically exosomes, induce specific cell-to-cell interactions and can activate …

Principles and problems of exosome isolation from biological fluids

EI Yakubovich, AG Polischouk… - … ), Supplement Series A …, 2022 - Springer
Exosomes, the subclass of small membrane extracellular vesicles, have great diagnostic
and therapeutic potential, but the lack of standardized methods for their efficient isolation …

Microfluidic strategies for the isolation and profiling of exosomes

J Bai, X Wei, X Zhang, C Wu, Z Wang, M Chen… - TrAC Trends in …, 2023 - Elsevier
Exosomes are nanoscale extracellular vesicles carrying various cargos, which play a
significant rule in intercellular communication, disease diagnosis and treatment …

Buoyant Metal–Organic Framework Corona-Driven Fast Isolation and Ultrasensitive Profiling of Circulating Extracellular Vesicles

X Qin, Y **ang, L Mao, Y Yang, B Wei, H Lu, X Li… - ACS …, 2024 - ACS Publications
Accurately assaying tumor-derived circulating extracellular vesicles (EVs) is fundamental in
noninvasive cancer diagnosis and therapeutic monitoring but limited by challenges in …

Direct isolation of small extracellular vesicles from human blood using viscoelastic microfluidics

Y Meng, Y Zhang, M Bühler, S Wang, M Asghari… - Science …, 2023 - science.org
Small extracellular vesicles (sEVs;< 200 nm) that contain lipids, nucleic acids, and proteins
are considered promising biomarkers for a wide variety of diseases. Conventional methods …

Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

Label-free isolation of exosomes using microfluidic technologies

S Hassanpour Tamrin, A Sanati Nezhad, A Sen - ACS nano, 2021 - ACS Publications
Exosomes are cell-derived structures packaged with lipids, proteins, and nucleic acids. They
exist in diverse bodily fluids and are involved in physiological and pathological processes …

Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis

Z Li, C Liu, Y Cheng, Y Li, J Deng, L Bai, L Qin… - Science …, 2023 - science.org
Tumor-derived extracellular vesicles (EVs) hold the potential to substantially improve
noninvasive early diagnosis of cancer. However, analysis of nanosized EVs in blood …