Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …

Cannabis sativa L. is a plant that contains numerous chemically active compounds including
cannabinoids such as trans-Δ-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) …

The central nervous system (CNS) is the major target for adverse effects of alcohol and
extensively promotes the development of a significant number of neurological diseases such …

Binge or chronic alcohol consumption causes neuroinflammation and leads to alcohol use
disorder (AUD). AUD not only affects the central nervous system (CNS) but also leads to …

Alzheimer's Disease and related dementias (ADRD) are an increasing threat to global
health initiatives. Efforts to prevent the development of ADRD require understanding …

Neurological diseases associated with pathogenic variants in a specific gene, or even with a
specific pathogenic variant, can show profound phenotypic variation with regard to symptom …

Alcohol consumption is a heritable behavior seriously endangers human health. However,
genetic studies on alcohol consumption primarily focuses on common variants, while …

Previous observational studies reported that midlife clustering of cardiovascular risk factors
and lifestyle behaviors were associated with neurodegenerative disease; however, these …