Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis

M Gharagozloo, JW Mace… - Frontiers in Molecular …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

[PDF][PDF] Repurposing ketamine in the therapy of depression and depression-related disorders: recent advances and future potential

Q Deng, E Parker, C Wu, L Zhu, TC Liu, R Duan… - Aging Dis, 2024 - scholar.archive.org
Depression represents a prevalent and enduring mental disorder of significant concern
within the clinical domain. Extensive research indicates that depression is very complex …

Neural stem cells and oligodendrocyte progenitor cells compete for remyelination in the corpus callosum

S Moyon, M Holloman, JL Salzer - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
A major therapeutic goal in demyelinating diseases, such as Multiple Sclerosis, is to improve
remyelination, thereby restoring effective axon conduction and preventing …

Visual evoked potentials to monitor myelin cuprizone-induced functional changes

S Marenna, SC Huang, G Dalla Costa, R d'Isa… - Frontiers in …, 2022 - frontiersin.org
The visual system is one of the most accessible routes to study the central nervous system
under pathological conditions, such as in multiple sclerosis (MS). Non-invasive visual …

Sulforaphane, an Nrf-2 agonist, modulates oxidative stress and inflammation in a rat model of cuprizone-induced cardiotoxicity and hepatotoxicity

G Ibrahim Fouad - Cardiovascular Toxicology, 2023 - Springer
Cuprizone (CPZ) is a neurotoxic agent that is used to induce demyelination and
neurotoxicity in rats. This study aimed to investigate the protective potential of sulforaphane …

Huperzine—A improved animal behavior in cuprizone-induced mouse model by alleviating demyelination and neuroinflammation

H Zhang, D Wang, J Sun, Y Wang, S Wu… - International Journal of …, 2022 - mdpi.com
Huperzine A (HupA) is a natural acetylcholinesterase inhibitor (AChEI) with the advantages
of high efficiency, selectivity as well as reversibility and can exhibit significant therapeutic …

Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro

Z Zha, YJ Liu, SS Liu, N Zhang, JL Li… - Oxidative medicine …, 2022 - Wiley Online Library
Background/Aims. Multiple sclerosis (MS) is an autoimmune disorder that affects the central
nervous system (CNS) primarily hallmarked by neuroinflammation and demyelination. The …

Comparative neuroprotective potential of nanoformulated and free resveratrol against cuprizone-induced demyelination in rats

SAM El-Sayed, GI Fouad, MZ Rizk, HH Beherei… - Molecular …, 2024 - Springer
Demyelination is a frequent yet crippling neurological disease associated with multiple
sclerosis (MS). The cuprizone (CZ) model, which causes demyelination through oxidative …

Lactoferrin, chitosan double-coated oleosomes loaded with clobetasol propionate for remyelination in multiple sclerosis: Physicochemical characterization and in-vivo …

LR Abdelalim, YSR Elnaggar, OY Abdallah - International Journal of …, 2024 - Elsevier
Multiple sclerosis is a chronic inflammatory demyelinating disorder of the CNS characterized
by continuous myelin damage accompanied by deterioration in functions. Clobetasol …

Sex differences in the behavioural aspects of the cuprizone-induced demyelination model in mice

KF Paton, S Hong, A Biggerstaff, BM Kivell - Brain Sciences, 2022 - mdpi.com
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central
nervous system. The cuprizone-induced demyelination model is often used in mice to test …