Exploring emergent properties in enzymatic reaction networks: design and control of dynamic functional systems

S Ghosh, MG Baltussen, NM Ivanov, R Haije… - Chemical …, 2024 - ACS Publications
The intricate and complex features of enzymatic reaction networks (ERNs) play a key role in
the emergence and sustenance of life. Constructing such networks in vitro enables stepwise …

Liposomes and polymersomes: a comparative review towards cell mimicking

E Rideau, R Dimova, P Schwille, FR Wurm… - Chemical society …, 2018 - pubs.rsc.org
Cells are integral to all forms of life due to their compartmentalization by the plasma
membrane. However, living organisms are immensely complex. Thus there is a need for …

Recent advances in permeable polymersomes: fabrication, responsiveness, and applications

Y Zhu, S Cao, M Huo, JCM van Hest, H Che - Chemical science, 2023 - pubs.rsc.org
Polymersomes are vesicular nanostructures enclosed by a bilayer-membrane self-
assembled from amphiphilic block copolymers, which exhibit higher stability compared with …

Enzymatic reaction-coupled, cooperative supramolecular polymerization

A Das, S Ghosh, A Mishra, A Som… - Journal of the …, 2024 - ACS Publications
Nature employs sophisticated mechanisms to precisely regulate self-assembly and functions
within biological systems, exemplified by the formation of cytoskeletal filaments. Various …

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy

W Yang, G Zhu, S Wang, G Yu, Z Yang, L Lin, Z Zhou… - ACS …, 2019 - ACS Publications
A cancer vaccine is an important form of immunotherapy. Given their effectiveness for
antigen processing and presentation, dendritic cells (DCs) have been exploited in the …

Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells

S Liu, Y Zhang, M Li, L **ong, Z Zhang, X Yang… - Nature Chemistry, 2020 - nature.com
The design and construction of synthetic therapeutic protocells capable of establishing
cognate chemical communication channels with living cells is an important challenge for …

Chemically fueled supramolecular materials

X Chen, MA Würbser… - Accounts of Materials …, 2023 - ACS Publications
Conspectus In biology, the function of many molecules is regulated through nonequilibrium
chemical reaction cycles. The prototypical example is the phosphorylation of an amino acid …

Versatile phospholipid assemblies for functional synthetic cells and artificial tissues

X Wang, H Du, Z Wang, W Mu, X Han - Advanced Materials, 2021 - Wiley Online Library
The bottom‐up construction of a synthetic cell from nonliving building blocks capable of
mimicking cellular properties and behaviors helps to understand the particular biophysical …

Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors

O Rifaie-Graham, J Yeow, A Najer, R Wang, R Sun… - Nature Chemistry, 2023 - nature.com
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled
by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem …

The hallmarks of living systems: towards creating artificial cells

NA Yewdall, AF Mason, JCM Van Hest - Interface Focus, 2018 - royalsocietypublishing.org
Despite the astonishing diversity and complexity of living systems, they all share five
common hallmarks: compartmentalization, growth and division, information processing …