Antiangiogenic–immune-checkpoint inhibitor combinations: Lessons from phase III clinical trials

HY Kuo, KA Khan, RS Kerbel - Nature Reviews Clinical Oncology, 2024 - nature.com
Antiangiogenic agents, generally antibodies or tyrosine-kinase inhibitors that target the
VEGF–VEGFR pathway, are currently among the few combination partners clinically proven …

Big data and artificial intelligence in cancer research

X Wu, W Li, H Tu - Trends in cancer, 2024 - cell.com
The field of oncology has witnessed an extraordinary surge in the application of big data and
artificial intelligence (AI). AI development has made multiscale and multimodal data fusion …

Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

X Chen, J Li, S Roy, Z Ullah, J Gu… - Advanced …, 2024 - Wiley Online Library
Fluorescence imaging in the second near‐infrared window (NIR‐II) is burgeoning because
of its higher imaging fidelity in monitoring physiological and pathological processes than …

Recent progress of microneedles in transdermal immunotherapy: a review

X Ai, J Yang, Z Liu, T Guo, N Feng - International Journal of Pharmaceutics, 2024 - Elsevier
Since human skin is an immune organ, a large number of immune cells are distributed in the
epidermis and the dermis of the skin. Transdermal immunotherapy shows great therapeutic …

[HTML][HTML] Immunotherapy for hepatocellular carcinoma

A Childs, G Aidoo-Micah, MK Maini, T Meyer - JHEP Reports, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a major global healthcare challenge, with> 1 million
patients predicted to be affected annually by 2025 1. In contrast to other cancers, both …

Integration of clinical trial spatial multiomics analysis and virtual clinical trials enables immunotherapy response prediction and biomarker discovery

S Zhang, A Deshpande, BK Verma, H Wang… - Cancer …, 2024 - aacrjournals.org
Due to the lack of treatment options, there remains a need to advance new therapeutics in
hepatocellular carcinoma (HCC). The traditional approach moves from initial molecular …

Understanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment

J Yu, X Chen, X Yang, B Zhang - Trends in Endocrinology & Metabolism, 2024 - cell.com
The gut microbiome can play a crucial role in hepatocellular carcinoma (HCC) progression
through the enterohepatic circulation, primarily acting via metabolic reprogramming and …

Intelligent Modular DNA Lysosome-Targeting Chimera Nanodevice for Precision Tumor Therapy

M Cui, D Zhang, X Zheng, H Zhai, M **e… - Journal of the …, 2024 - ACS Publications
Lysosome targeting chimeras (LYTACs) have emerged as a powerful modality that can
eliminate traditionally undruggable extracellular tumor-related pathogenic proteins, but their …

Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment

Y Liu, H Yang, T Li, N Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

JJ Urquijo-Ponce, C Alventosa-Mateu… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a high mortality neoplasm which usually appears on a
cirrhotic liver. The therapeutic arsenal and subsequent prognostic outlook are intrinsically …