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Antiangiogenic–immune-checkpoint inhibitor combinations: Lessons from phase III clinical trials
Antiangiogenic agents, generally antibodies or tyrosine-kinase inhibitors that target the
VEGF–VEGFR pathway, are currently among the few combination partners clinically proven …
VEGF–VEGFR pathway, are currently among the few combination partners clinically proven …
Big data and artificial intelligence in cancer research
The field of oncology has witnessed an extraordinary surge in the application of big data and
artificial intelligence (AI). AI development has made multiscale and multimodal data fusion …
artificial intelligence (AI). AI development has made multiscale and multimodal data fusion …
Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy
Fluorescence imaging in the second near‐infrared window (NIR‐II) is burgeoning because
of its higher imaging fidelity in monitoring physiological and pathological processes than …
of its higher imaging fidelity in monitoring physiological and pathological processes than …
Recent progress of microneedles in transdermal immunotherapy: a review
X Ai, J Yang, Z Liu, T Guo, N Feng - International Journal of Pharmaceutics, 2024 - Elsevier
Since human skin is an immune organ, a large number of immune cells are distributed in the
epidermis and the dermis of the skin. Transdermal immunotherapy shows great therapeutic …
epidermis and the dermis of the skin. Transdermal immunotherapy shows great therapeutic …
[HTML][HTML] Immunotherapy for hepatocellular carcinoma
A Childs, G Aidoo-Micah, MK Maini, T Meyer - JHEP Reports, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a major global healthcare challenge, with> 1 million
patients predicted to be affected annually by 2025 1. In contrast to other cancers, both …
patients predicted to be affected annually by 2025 1. In contrast to other cancers, both …
Integration of clinical trial spatial multiomics analysis and virtual clinical trials enables immunotherapy response prediction and biomarker discovery
Due to the lack of treatment options, there remains a need to advance new therapeutics in
hepatocellular carcinoma (HCC). The traditional approach moves from initial molecular …
hepatocellular carcinoma (HCC). The traditional approach moves from initial molecular …
Understanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment
J Yu, X Chen, X Yang, B Zhang - Trends in Endocrinology & Metabolism, 2024 - cell.com
The gut microbiome can play a crucial role in hepatocellular carcinoma (HCC) progression
through the enterohepatic circulation, primarily acting via metabolic reprogramming and …
through the enterohepatic circulation, primarily acting via metabolic reprogramming and …
Intelligent Modular DNA Lysosome-Targeting Chimera Nanodevice for Precision Tumor Therapy
M Cui, D Zhang, X Zheng, H Zhai, M **e… - Journal of the …, 2024 - ACS Publications
Lysosome targeting chimeras (LYTACs) have emerged as a powerful modality that can
eliminate traditionally undruggable extracellular tumor-related pathogenic proteins, but their …
eliminate traditionally undruggable extracellular tumor-related pathogenic proteins, but their …
Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment
Y Liu, H Yang, T Li, N Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …
related deaths worldwide. Despite advances in medical research, the prognosis for liver …
Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma
JJ Urquijo-Ponce, C Alventosa-Mateu… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a high mortality neoplasm which usually appears on a
cirrhotic liver. The therapeutic arsenal and subsequent prognostic outlook are intrinsically …
cirrhotic liver. The therapeutic arsenal and subsequent prognostic outlook are intrinsically …