Targeting biomolecular condensation and protein aggregation against cancer
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …
separation, hold dichotomous roles in health and disease. Alongside their physiological …
Physiological functions of the cellular prion protein
AR Castle, AC Gill - Frontiers in molecular biosciences, 2017 - frontiersin.org
The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …
Physiology of the prion protein
Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …
[HTML][HTML] The cellular prion protein (PrPC): its physiological function and role in disease
L Westergard, HM Christensen, DA Harris - Biochimica et Biophysica Acta …, 2007 - Elsevier
Prion diseases are caused by conversion of a normal cell-surface glycoprotein (PrPC) into a
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …
conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid …
p53 in neuronal apoptosis
The tumor suppressor and transcription factor p53 is a key modulator of cellular stress
responses, and activation of p53 can trigger apoptosis in many cell types including neurons …
responses, and activation of p53 can trigger apoptosis in many cell types including neurons …
Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP
R Pardossi-Piquard, A Petit, T Kawarai, C Sunyach… - Neuron, 2005 - cell.com
Amyloid β-peptide (Aβ), which plays a central role in Alzheimer's disease, is generated by
presenilin-dependent γ-secretase cleavage of β-amyloid precursor protein (βAPP). We …
presenilin-dependent γ-secretase cleavage of β-amyloid precursor protein (βAPP). We …
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
H Guo, D Liu, H Gelbard, T Cheng, R Insalaco… - Neuron, 2004 - cell.com
Activated protein C (APC), a serine protease with anticoagulant and anti-inflammatory
activities, exerts direct cytoprotective effects on endothelium via endothelial protein C …
activities, exerts direct cytoprotective effects on endothelium via endothelial protein C …
Lethal recessive myelin toxicity of prion protein lacking its central domain
PrPC‐deficient mice expressing prion protein variants with large amino‐proximal deletions
(termed PrPΔF) suffer from neurodegeneration, which is rescued by full‐length PrPC. We …
(termed PrPΔF) suffer from neurodegeneration, which is rescued by full‐length PrPC. We …
The function of the cellular prion protein in health and disease
The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …
The α-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo
MV Guillot-Sestier, C Sunyach, C Druon… - Journal of Biological …, 2009 - ASBMB
Cellular prion protein (PrP c) undergoes a disintegrin-mediated physiological cleavage,
generating a soluble amino-terminal fragment (N1), the function of which remained …
generating a soluble amino-terminal fragment (N1), the function of which remained …