Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview
J Zhao, J Yang, Y **e - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …
Herbal nano-formulations for topical delivery
The use of herbal medicines has gained popularity throughout the world in recent times.
Often seen as natural alternatives with fewer side-effects than synthetic medicines, these …
Often seen as natural alternatives with fewer side-effects than synthetic medicines, these …
Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential
DR Telange, AT Patil, AM Pethe, H Fegade… - European Journal of …, 2017 - Elsevier
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …
Cyclodextrins as drug carriers in pharmaceutical technology: the state of the art
Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …
Colloidal and vesicular delivery system for herbal bioactive constituents
Objectives The main objective of the present review is to explore and examine the
effectiveness of currently developed novel techniques to resolve the issues which are …
effectiveness of currently developed novel techniques to resolve the issues which are …
Cyclodextrin and phospholipid complexation in solubility and dissolution enhancement: a critical and meta-analysis
A Semalty - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Poor solubility and dissolution of drugs are the major challenges in drug
formulation and delivery. In order to improve the solubility and dissolution profile of drugs …
formulation and delivery. In order to improve the solubility and dissolution profile of drugs …
The systems of naringenin with solubilizers expand its capability to prevent neurodegenerative diseases
A Stasiłowicz-Krzemień, M Gołębiewski… - International Journal of …, 2022 - mdpi.com
Background: Naringenin (NAR) is a flavonoid with excellent antioxidant and neuroprotective
potential that is limited by its low solubility. Thus, solid dispersions with β-cyclodextrin (β …
potential that is limited by its low solubility. Thus, solid dispersions with β-cyclodextrin (β …
Improved antioxidant, antimicrobial and anticancer activity of naringenin on conjugation with pectin
The purpose of the present study was to improve the aqueous solubility of naringenin by
conjugating with water-soluble polysaccharide carrier, pectin. The pectin–naringenin …
conjugating with water-soluble polysaccharide carrier, pectin. The pectin–naringenin …
A detailed computational study on binding of kinase inhibitors into β-cyclodextrin: Inclusion complex formation
It is well known that the limited aqueous solubility of some drugs often reduces their
bioavailability to targets. Inclusion complex formation of drugs with β-cyclodextrin is one of …
bioavailability to targets. Inclusion complex formation of drugs with β-cyclodextrin is one of …
Phytomedicinal flavonoid loaded phospholipid sheathed lipidic nano-carriers as a platform with boosted oral anti-mycobacterium activity
Naringenin (NAR) has recently been proven to exert antituberculosis activity (anti-TB);
however, because of its poor solubility and limited oral bioavailability, this is not enough for …
however, because of its poor solubility and limited oral bioavailability, this is not enough for …