Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation
This work presents a bird's eye view depicting current trends in the pharmaceutical industry
and the role of mathematical modeling in process design and operation within the …
and the role of mathematical modeling in process design and operation within the …
An integrated data management and informatics framework for continuous drug product manufacturing processes: A case study on two pilot plants
The pharmaceutical industry continuously looks for ways to improve its development and
manufacturing efficiency. In recent years, such efforts have been driven by the transition from …
manufacturing efficiency. In recent years, such efforts have been driven by the transition from …
Digital Design of Cooling Crystallization Processes Using a Machine Learning-Based Strategy
This study introduces a novel machine learning-based digital design strategy for predicting
the final yield and particle size distribution (PSD) in cooling crystallization processes. The …
the final yield and particle size distribution (PSD) in cooling crystallization processes. The …
Using PharmaPy with Jupyter Notebook to teach digital design in pharmaceutical manufacturing
The use of digital tools in pharmaceutical manufacturing has gained traction over the past
two decades. Whether supporting regulatory filings or attempting to modernize …
two decades. Whether supporting regulatory filings or attempting to modernize …
Dynamic Optimization for Petrophysical Property Estimation in Unsteady-State Coreflooding Using Pyomo
This paper deals with a mathematical modeling and optimization-based approach for
estimating relative permeability and capillary pressure from average water saturation data …
estimating relative permeability and capillary pressure from average water saturation data …
OPTIMIZATION TECHNIQUES FOR PHARMACEUTICAL MANUFACTURING AND DESIGN SPACE ANALYSIS
DJ Laky - 2022 - hammer.purdue.edu
In this dissertation, numerical analysis frameworks and software tools for digital design of
process systems are developed. More specifically, these tools have been focused on digital …
process systems are developed. More specifically, these tools have been focused on digital …
Digital Twin Development and Advanced Process Control for Continuous Pharmaceutical Manufacturing
YS Huang - 2023 - hammer.purdue.edu
To apply Industry 4.0 technologies and accelerate the modernization of continuous
pharmaceutical manufacturing, digital twin (DT) and advanced process control (APC) …
pharmaceutical manufacturing, digital twin (DT) and advanced process control (APC) …
[PDF][PDF] Hybrid Rule-based and Optimization-driven Decision Framework for the Rapid Synthesis of End-to-End Optimal (E2EO) and Sustainable Pharmaceutical …
Y Barhatea, D Casas-Orozcoa, DJ Lakya… - psecommunity.org
In this paper, a hybrid heuristic rule-based and deterministic optimization-driven process
decision framework is presented for the analysis and optimization of process flowsheets for …
decision framework is presented for the analysis and optimization of process flowsheets for …