Macrophage M1/M2 polarization

C Yunna, H Mengru, W Lei, C Weidong - European journal of …, 2020 - Elsevier
Macrophages can be affected by a variety of factors to change their phenotype and thus
affect their function. Activated macrophages are usually divided into two categories, M1-like …

Engineered biomaterials for in situ tissue regeneration

AK Gaharwar, I Singh, A Khademhosseini - Nature Reviews Materials, 2020 - nature.com
In situ tissue regeneration harnesses the body's regenerative potential to control cell
functions for tissue repair. The design of biomaterials for in situ tissue engineering requires …

Snail-inspired AFG/GelMA hydrogel accelerates diabetic wound healing via inflammatory cytokines suppression and macrophage polarization

Z Zhou, T Deng, M Tao, L Lin, L Sun, X Song, D Gao… - Biomaterials, 2023 - Elsevier
Diabetic foot ulcers (DFUs) are a severe and rapidly growing diabetic complication, but
treating DFUs remains a challenge for the existing therapies are expensive and highly non …

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing

H Atcha, A Jairaman, JR Holt, VS Meli… - Nature …, 2021 - nature.com
Macrophages perform diverse functions within tissues during immune responses to
pathogens and injury, but molecular mechanisms by which physical properties of the tissue …

Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

S Butenko, RR Nagalla, CF Guerrero-Juarez… - Nature …, 2024 - nature.com
Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …

Immunomodulatory biomaterials for tissue repair

R Whitaker, B Hernaez-Estrada, RM Hernandez… - Chemical …, 2021 - ACS Publications
All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes

P Krzyszczyk, R Schloss, A Palmer… - Frontiers in …, 2018 - frontiersin.org
Macrophages play key roles in all phases of adult wound healing, which are inflammation,
proliferation, and remodeling. As wounds heal, the local macrophage population transitions …

Dealing with the foreign‐body response to implanted biomaterials: strategies and applications of new materials

D Zhang, Q Chen, C Shi, M Chen, K Ma… - Advanced Functional …, 2021 - Wiley Online Library
Foreign‐body response caused by implanted biomaterials seriously impedes the function of
implants and is a major obstacle to the development of implantable biomaterials and …