Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from slee** and waking to neurotransmitter secretion and cellular metabolism …

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

Dynamic aspects of melatonin's actions merit increasing future attention. This concerns
particularly entirely different effects in senescent, weakened oscillators and in dysregulated …

Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …

The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …

In this study, we demonstrate that the lack of retinoic acid-related orphan receptor (ROR) γ or
α expression in mice significantly reduced the peak expression level of Cry1, Bmal1, E4bp4 …

Physiological function and metabolic regulation are the most important outputs of circadian
clock controls in mammals. Mitochondrial respiration and ROS production show rhythmic …

Transcription plays a central role in defining the identity and functionalities of cells, as well
as in their responses to changes in the cellular environment. The Gene Ontology (GO) …

Circadian rhythms govern a wide variety of physiological and metabolic functions in almost
all organisms. These are controlled by the circadian clock machinery, which is mostly based …