GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

FM Lang, KMC Lee, JR Teijaro, B Becher… - Nature Reviews …, 2020 - nature.com
Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed.
Granulocyte–macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor …

GM-CSF in inflammation

JA Hamilton - Journal of Experimental Medicine, 2019 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

Molecular dynamics of lipopolysaccharide-induced lung injury in rodents

H Domscheit, MA Hegeman, N Carvalho… - Frontiers in …, 2020 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a common disease entity in critical care
medicine and is still associated with a high mortality. Because of the heterogeneous …

Colony-stimulating factors in inflammation and autoimmunity

JA Hamilton - Nature Reviews Immunology, 2008 - nature.com
Although they were originally defined as haematopoietic-cell growth factors, colony-
stimulating factors (CSFs) have been shown to have additional functions by acting directly …

Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination

A Rostami, B Ciric - Journal of the neurological sciences, 2013 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The
etiology of MS is not well understood, but it is believed that myelin-specific CD4+ T cells play …

GM-CSF: a promising target in inflammation and autoimmunity

KMC Lee, AA Achuthan, JA Hamilton - ImmunoTargets and …, 2020 - Taylor & Francis
The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly
identified as being able to induce in vitro the proliferation and differentiation of bone marrow …

Colony stimulating factors and myeloid cell biology in health and disease

JA Hamilton, A Achuthan - Trends in immunology, 2013 - cell.com
The colony stimulating factors (CSFs), granulocyte macrophage-CSF (GM-CSF),
macrophage-CSF (M-CSF or CSF-1) and granulocyte-CSF (G-CSF) were first identified as in …

Cytokine networking of innate immunity cells: a potential target of therapy

I Striz, E Brabcova, L Kolesar, A Sekerkova - Clinical science, 2014 - portlandpress.com
Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Cytokine inhibition in the treatment of COPD

G Caramori, IM Adcock, A Di Stefano… - International journal of …, 2014 - Taylor & Francis
Cytokines play an important part in many pathobiological processes of chronic obstructive
pulmonary disease (COPD), including the chronic inflammatory process, emphysema, and …

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

TR Hercus, D Thomas, MA Guthridge… - Blood, The Journal …, 2009 - ashpublications.org
Already 20 years have passed since the cloning of the granulocyte-macrophage colony-
stimulating factor (GM-CSF) receptor α-chain, the first member of the GM-CSF/interleukin (IL) …