Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Negative symptoms of schizophrenia: new developments and unanswered research questions

S Galderisi, A Mucci, RW Buchanan… - The Lancet Psychiatry, 2018 - thelancet.com
Negative symptoms of schizophrenia are associated with poor functional outcome and place
a substantial burden on people with this disorder, their families, and health-care systems …

EPA guidance on assessment of negative symptoms in schizophrenia

S Galderisi, A Mucci, S Dollfus, M Nordentoft… - European …, 2021 - cambridge.org
BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

Comprehensive versus usual community care for first-episode psychosis: 2-year outcomes from the NIMH RAISE early treatment program

JM Kane, DG Robinson, NR Schooler… - American Journal of …, 2016 - psychiatryonline.org
Objective: The primary aim of this study was to compare the impact of NAVIGATE, a
comprehensive, multidisciplinary, team-based treatment approach for first-episode …

The influence of illness‐related variables, personal resources and context‐related factors on real‐life functioning of people with schizophrenia

S Galderisi, A Rossi, P Rocca, A Bertolino… - World …, 2014 - Wiley Online Library
In people suffering from schizophrenia, major areas of everyday life are impaired, including
independent living, productive activities and social relationships. Enhanced understanding …

Factors associated with real-life functioning in persons with schizophrenia in a 4-year follow-up study of the Italian network for research on psychoses

A Mucci, S Galderisi, D Gibertoni, A Rossi… - JAMA …, 2021 - jamanetwork.com
Importance The goal of schizophrenia treatment has shifted from symptom reduction and
relapse prevention to functional recovery; however, recovery rates remain low. Prospective …

Meta-analysis of the positive and Negative Syndrome Scale (PANSS) factor structure

A Shafer, F Dazzi - Journal of Psychiatric Research, 2019 - Elsevier
A meta-analysis of the results of 45 factor analyses (n= 22,812) of the Positive and Negative
Syndrome Scale (PANSS) was conducted. Meta-analyses of the PANSS was conducted …

Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review

B Misiak, B Stańczykiewicz, K Kotowicz… - Schizophrenia …, 2018 - Elsevier
Background The aim of this article was to perform a systematic review of studies
investigating the association between peripheral levels of cytokines and C-reactive protein …

Negative symptoms of schizophrenia: clinical features, relevance to real world functioning and specificity versus other CNS disorders

G Foussias, O Agid, G Fervaha, G Remington - European …, 2014 - Elsevier
Negative symptoms have long been recognized as a central feature of the phenomenology
of schizophrenia, dating back to the early descriptions by Kraepelin and Bleuler. Over the …

The interplay among psychopathology, personal resources, context‐related factors and real‐life functioning in schizophrenia: stability in relationships after 4 years and …

S Galderisi, P Rucci, A Mucci, A Rossi… - World …, 2020 - Wiley Online Library
Improving real‐life functioning is the main goal of the most advanced integrated treatment
programs in people with schizophrenia. The Italian Network for Research on Psychoses …