Introduction Phenytoin has complex pharmacokinetics. The intravenous loading dose of
phenytoin for children in status epilepticus has recently been increased from 18 to 20 mg/kg …

Purpose To use a physiologically based pharmacokinetic (PBPK) modelling system to
predict the serum levels achieved by two different intravenous loading doses of phenytoin …

Background: Epileptic seizures are a relatively common problem in pediatric neurosurgery
that can have physical, mental and/or behavioral implications. Pediatric neurosurgery is …

Introduction We aimed to evaluate the pediatric fosphenytoin dosing regimen, including
optimal timing for the measurement of total serum phenytoin concentration (C PHT) …

Aim: To evaluate the knowledge levels and attitudes of physicians regarding acute
management of seizures in pediatric patients. Conclusion: There is a wide variation in …

Status epilepticus is a serious medical emergency characterised either by continued
seizures or by a lack of full recovery between seizures. People with status epilepticus …

People with recurrent, prolonged or continuous seizures require urgent intervention to limit
their risk of neurological harm and death. Adherence to standard management protocols …

Methods A phenytoin pharmacokinetic model was used in the Simcyp™ population-based
ADME simulator, simulating 100 children age 2-10 years receiving intravenous phenytoin …