Activity-based hydrazine probes for protein profiling of electrophilic functionality in therapeutic targets
Most known probes for activity-based protein profiling (ABPP) use electrophilic groups that
tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity …
tag a single type of nucleophilic amino acid to identify cases in which its hyper-reactivity …
Proteomic approaches to study SARS-CoV-2 biology and COVID-19 pathology
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative
agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March …
agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March …
The evolution of small molecule enzyme activators
LF Dow, AM Case, MP Paustian, BR Pinkerton… - RSC Medicinal …, 2023 - pubs.rsc.org
There is a myriad of enzymes within the body responsible for maintaining homeostasis by
providing the means to convert substrates to products as and when required. Physiological …
providing the means to convert substrates to products as and when required. Physiological …
Activity-based protein profiling in drug/pesticide discovery: Recent advances in target identification of antibacterial compounds
K Chen, L Zhang, Y Ding, Z Sun, J Meng, R Luo… - Bioorganic …, 2024 - Elsevier
Given the escalating incidence of bacterial diseases and the challenge posed by pathogenic
bacterial resistance, it is imperative to identify appropriate methodologies for conducting …
bacterial resistance, it is imperative to identify appropriate methodologies for conducting …
N-Phenyl-1-(phenylsulfonyl)-1H-1,2,4-triazol-3-amine as a New Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor
T Lane, V Makarov, JAE Nelson… - Journal of medicinal …, 2023 - ACS Publications
Highly active antiretroviral therapy (HAART) has revolutionized human immunodeficiency
virus (HIV) healthcare, turning it from a terminal to a potentially chronic disease, although …
virus (HIV) healthcare, turning it from a terminal to a potentially chronic disease, although …